Coughex

Gefapixant is a selective antagonist of the P2X3 receptor. Gefapixant also has activity against the P2X2/3 receptor subtype. P2X3-containing receptors belong to the family of purinergic receptors and are ATP-gated ion channels found among sensory C fibers of the vagus nerve in the airways. C fibers are activated in response to inflammation or chemical irritants.

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