Nebinex

Nebivolol (Nebinex) is indicated in the treatment of essential hypertension and adjunct in stable mild to moderate heart failure in patients over 70 years.

Pharmacodynamics: Nebivolol is a β-adrenergic receptor blocking agent. Nebivolol is a racemate of two enantiomers, d-Nebivolol and l-Nebivolol. Nebivolol has unique pharmacologic properties, including very high selectivity for β-1 receptor and nitric oxide-mediated vasodilatory effect. Pharmacokinetics: Nebivolol is metabolized by a number of routes, including glucuronidation and hydroxylation by CYP2D6. The active isomer (d-Nebivolol) has an effective half-life of about 12 hours in extensive metabolizers (most people), and 19 hours in poor metabolizers. Mean peak plasma Nebivolol concentrations occur approximately 1.5 to 4 hours. Plasma protein binding of Nebivolol is approximately 98%, mostly to albumin. 

Features