Savesto

Savesto is a combination of Sacubitril & Valsartan. Sacubitril, a neprilysin inhibitor that inhibits neprilysin (neutral endopeptidase; NEP) via active metabolite of the prodrug Sacubitril. Valsartan, an angiotensin receptor blocker that blocks the angiotensin II type-1 (AT1) receptor. The cardiovascular and renal effects of Sacubitril / Valsartan in heart failure patients are attributed to the increased levels of peptides that are degraded by neprilysin, such as natriuretic peptides by the active metabolite of Sacubitril and the simultaneous inhibition of the effects of angiotensin II by Valsartan. Valsartan inhibits the effects of angiotensin II by selectively blocking the AT1 receptor, and also inhibits angiotensin II-dependent aldosterone release.

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